Common Bulkhead Joint Development and Evaluation Final Report

Optimized composite welded joint design for Saturn booster common bulkhea

Decolonizing Native Histories

Decolonizing Native Histories is an interdisciplinary collection that grapples with the racial and ethnic politics of knowledge production and indigenous activism in the Americas. It analyzes the relationship of language to power and empowerment, and advocates for collaborations between community members, scholars, and activists that prioritize the rights of Native peoples to decide how their knowledge is used. The contributors—academics and activists, indigenous and nonindigenous, from disciplines including history, anthropology, linguistics, and political science—explore the challenges of decolonization. These wide-ranging case studies consider how language, the law, and the archive have historically served as instruments of colonialism and how they can be creatively transformed in constructing autonomy. The collection highlights points of commonality and solidarity across geographical, cultural, and linguistic boundaries and also reflects deep distinctions between North and South. Decolonizing Native Histories looks at Native histories and narratives in an internationally comparative context, with the hope that international collaboration and understanding of local histories will foster new possibilities for indigenous mobilization and an increasingly decolonized future

Decolonizing Native Histories

Decolonizing Native Histories is an interdisciplinary collection that grapples with the racial and ethnic politics of knowledge production and indigenous activism in the Americas. It analyzes the relationship of language to power and empowerment, and advocates for collaborations between community members, scholars, and activists that prioritize the rights of Native peoples to decide how their knowledge is used. The contributors—academics and activists, indigenous and nonindigenous, from disciplines including history, anthropology, linguistics, and political science—explore the challenges of decolonization. These wide-ranging case studies consider how language, the law, and the archive have historically served as instruments of colonialism and how they can be creatively transformed in constructing autonomy. The collection highlights points of commonality and solidarity across geographical, cultural, and linguistic boundaries and also reflects deep distinctions between North and South. Decolonizing Native Histories looks at Native histories and narratives in an internationally comparative context, with the hope that international collaboration and understanding of local histories will foster new possibilities for indigenous mobilization and an increasingly decolonized future

Recommendations for HER2 testing in the UK

Determining the HER2 status of breast carcinomas is a prerequisite for the use of the monoclonal antibody trastuzumab (Herceptin(R)), which has recently been licensed for the treatment of metastatic disease. This necessitates a test based on archival material. The preferred analyses are immunohistochemistry with fluorescent in situ hybridisation (FISH) as a follow up test for ambiguous results. Guidelines have been developed for standardised, well controlled procedures for the provision of reliable results. A group of three reference laboratories has been established to provide advice, quality assurance, and materials, where needed

Street railway equipment

Citation: Alexander, Lizzie Bea. Problems of bread making. Senior thesis, Kansas State Agricultural College, 1907.Morse Department of Special CollectionsIntroduction: Alternating current will perhaps in time supplant direct current for traction purposes as it did in lighting, with the advent of the long distance high potential transmission, but as yet the direct current plays a very important part in both power and traction. It has however the disadvantage of being difficult to transmit long distances without great loss. This is due to the inherent limitations in the production of high voltages from the direct current generator. Commutation at voltages sufficiently high to warrant economical transmission over long distances, is extremely difficult. Sparking and other difficulties at once arise which place the voltage within the limitations mentioned. The alternating current generator has not only the advantage of higher voltage, but by means of suitable transformer devices the voltage may be raised to any desired value for economical transmission. It will be readily seen, therefore, that alternating current machinery will supplant the direct current for traction purposes. In this thesis only direct current is treated. Direct current on a small scale and for local distribution fulfills more nearly the requirements demanded for traction purposes such as is needed on railways. The discussions are confined to the electrical equipment of the car only, the mechanical construction being referred to only as needed in line with the electrical connections

Fiduciary Tool Kit for Compliance: Common Errors in Qualified and Nonqualified Retirement Plan Administration

The Investment Company Institute reported that U.S. retirement plan assets reached $21.7 trillion as of Sept. 30, 2013, which represents 34 percent of all household financial assets in the U.S.1 The Department of Labor reported in June 2013 that 88.7 million Americans have defined contribution plan accounts, based on data from 2011 annual reports.2 With so many millions of people depending on these plans for retirement security, the government has placed significant legal requirements on the role of fiduciaries. Employers that sponsor retirement plans are being put under an increasingly high degree of scrutiny for their actions and inactions with respect to the qualified and nonqualified plans that they sponsor. Plan sponsors are subject to fiduciary standards, but do not always understand their role and obligations as a fiduciary. To comply with the plethora of duties and requirements governing plans, plan sponsors must understand their role as a fiduciary, identify plan errors and resolve those errors to reduce risks of noncompliance and exposure to fiduciary liability and penalties

Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection

Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors. To elucidate these factors could help to develop new medical treatments and tools to identify those most at risk. In recent years genome wide association studies (GWAS) in mice and humans have proved successful in identification of causal genes involved in many complex diseases for example diabetes, systemic lupus or cholesterol metabolism. In this study a GWAS approach was used to map genetic loci associated with susceptibility to pneumococcal infection in 26 inbred mouse strains. As a result four candidate QTLs were identified on chromosomes 7, 13, 18 and 19. Interestingly, the QTL on chromosome 7 was located within S. pneumoniae resistance QTL (Spir1) identified previously in a linkage study of BALB/cOlaHsd and CBA/CaOlaHsd F2 intercrosses. We showed that only a limited number of genes encoded within the QTLs carried phenotype-associated polymorphisms (22 genes out of several hundred located within the QTLs). These candidate genes are known to regulate TGFb signalling, smooth muscle and immune cells functions. Interestingly, our pulmonary histopathology and gene expression data demonstrated, lung vasculature plays an important role in resistance to pneumococcal infection. Therefore we concluded that the cumulative effect of these candidate genes on vasculature and immune cells functions as contributory factors in the observed differences in susceptibility to pneumococcal infection. We also propose that TGFbmediated regulation of fibroblast differentiation plays an important role in development of invasive pneumococcal disease.This work was supported by the European Union-funded Pneumopath Project HEALTH-F3-2009-222983. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer-reviewedPublisher Versio